Assay Detail
Functional
CHEMBL701912
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Concentration required to inhibit the rate of platelet aggregation by 50% was determined with human gel filtered platelets (GFP)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Non-peptide fibrinogen receptor antagonists. 7. Design and synthesis of a potent, orally active fibrinogen receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.01 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48371 | — | — | 1 | 7.50 |
| CHEMBL113366 | — | — | 1 | 7.08 |
| CHEMBL322822 | — | — | 1 | 6.17 |
| CHEMBL324502 | — | — | 1 | 5.11 |
| CHEMBL112550 | — | — | 1 | 5.11 |
| CHEMBL114542 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48371 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL113366 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL322822 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL324502 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL112550 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL114542 | — | IC50 | = | 8400.0 | nM | 5.08 |