Assay Detail
Functional
CHEMBL701920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-induced TNF-alpha production in human whole blood.
23
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.00 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351187 | — | — | 3 | 7.00 |
| CHEMBL165687 | — | — | 1 | 6.70 |
| CHEMBL323312 | — | — | 1 | 6.52 |
| CHEMBL354931 | — | — | 1 | 6.52 |
| CHEMBL444865 | — | — | 1 | 6.52 |
| CHEMBL164564 | — | — | 1 | 6.40 |
| CHEMBL349635 | — | — | 1 | 6.40 |
| CHEMBL165889 | — | — | 1 | 6.16 |
| CHEMBL286224 | — | — | 1 | 6.16 |
| CHEMBL164199 | — | — | 1 | 6.10 |
| CHEMBL163311 | — | — | 1 | 6.10 |
| CHEMBL351007 | — | — | 1 | 6.10 |
| CHEMBL166299 | — | — | 1 | 6.05 |
| CHEMBL166297 | — | — | 1 | 6.00 |
| CHEMBL165298 | — | — | 1 | 5.80 |
| CHEMBL166245 | — | — | 1 | 5.77 |
| CHEMBL165773 | — | — | 1 | 5.75 |
| CHEMBL162485 | — | — | 1 | 5.68 |
| CHEMBL423252 | — | — | 1 | 5.42 |
| CHEMBL350627 | — | — | 1 | 4.77 |
| CHEMBL162870 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351187 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL351187 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL165687 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL323312 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL354931 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL444865 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL164564 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL349635 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL165889 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL286224 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL351007 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL163311 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL164199 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL166299 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL166297 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL165298 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL166245 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL165773 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL162485 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL423252 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL351187 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL350627 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL162870 | — | IC50 | = | 34000.0 | nM | 4.47 |