Assay Detail
Functional
CHEMBL701923
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-induced release of Tumor necrosis factor-alpha (TNF-alpha) from human whole blood
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Blood |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.18 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446404 | — | — | 1 | 9.40 |
| CHEMBL303144 | — | — | 1 | 8.55 |
| CHEMBL305178 | — | — | 1 | 8.37 |
| CHEMBL308939 | — | — | 1 | 8.22 |
| CHEMBL69331 | — | — | 1 | 7.47 |
| CHEMBL307435 | — | — | 1 | 7.30 |
| CHEMBL69764 | — | — | 1 | 6.76 |
| CHEMBL424418 | — | — | 1 | 6.72 |
| CHEMBL307980 | — | — | 1 | 6.54 |
| CHEMBL67874 | — | — | 1 | 6.23 |
| CHEMBL10 | SB-203580 | — | 1 | 6.00 |
| CHEMBL305749 | — | — | 1 | 4.62 |
| CHEMBL302805 | — | — | 1 | - |
| CHEMBL67633 | — | — | 1 | - |
| CHEMBL302728 | — | — | 1 | - |
| CHEMBL67658 | — | — | 1 | - |
| CHEMBL63135 | — | — | 1 | - |
| CHEMBL68572 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446404 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL303144 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL305178 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL308939 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL69331 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL307435 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL69764 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL424418 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL307980 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL67874 | — | IC50 | = | 585.0 | nM | 6.23 |
| CHEMBL10 | SB-203580 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL305749 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL302805 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL67633 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL302728 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL67658 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63135 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL68572 | — | IC50 | > | 100000.0 | nM | - |