Assay Detail
Functional
CHEMBL701928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-stimulated TNF-alpha production in human whole blood
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.06 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96345 | — | — | 1 | 8.40 |
| CHEMBL328242 | — | — | 1 | 8.25 |
| CHEMBL318934 | — | — | 1 | 8.15 |
| CHEMBL419134 | — | — | 1 | 8.12 |
| CHEMBL316604 | — | — | 1 | 8.00 |
| CHEMBL419140 | — | — | 1 | 7.91 |
| CHEMBL264627 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96345 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL328242 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL318934 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL419134 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL316604 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL419140 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL264627 | — | IC50 | = | 27.1 | nM | 7.57 |