Assay Detail
Functional
CHEMBL702014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity for [Ca2+] permeable Ionotropic glutamate receptor AMPA expressed in Xenopus oocytes by injection of rat brain mRNA
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Oocyte |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis of polyamine derivatives having non-hypotensive Ca2 +-permeable AMPA receptor antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.33 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23651 | — | — | 1 | 6.77 |
| CHEMBL22366 | — | — | 1 | 6.72 |
| CHEMBL23652 | — | — | 1 | 6.58 |
| CHEMBL283157 | — | — | 1 | 6.57 |
| CHEMBL22371 | — | — | 1 | 6.50 |
| CHEMBL22614 | — | — | 1 | 6.48 |
| CHEMBL25440 | — | — | 1 | 6.38 |
| CHEMBL22324 | — | — | 1 | 6.31 |
| CHEMBL23648 | — | — | 1 | 6.24 |
| CHEMBL25101 | — | — | 1 | 6.16 |
| CHEMBL25214 | — | — | 1 | 6.14 |
| CHEMBL22248 | — | — | 1 | 6.11 |
| CHEMBL277002 | — | — | 1 | 6.09 |
| CHEMBL23030 | — | — | 1 | 5.96 |
| CHEMBL422754 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23651 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL22366 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL23652 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL283157 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL22371 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL22614 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL25440 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL22324 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL23648 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL25101 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL25214 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL22248 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL277002 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL23030 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL422754 | — | IC50 | = | 1300.0 | nM | 5.89 |