Compound Detail
CHEMBL283157
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NC(=O)C[C@@H](NC(=O)Cc1cccc2ccccc12)C(=O)N1CCC(CNCCCCNCC2CCNCC2)CC1
Basic Information
| ChEMBL ID | CHEMBL283157 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XGXUQCIUYQNBJR-GDLZYMKVSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
564.8
MW (Da)
1.94
ALogP
6
HBA
5
HBD
128.6
PSA (Ų)
0.21
QED
1
Ro5 Violations
15
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 6.57 | 6.57 | 270.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 270.0 | nM | 6.57 | Antagonist activity for [Ca2+] permeable Ionotropic glutamate receptor AMPA expr... | 11392532 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11392532 | 10.1016/s0960-894x(01)00170-6 | Glutamate receptor ionotropic, AMPA | 1 |
| 11392532 | 10.1016/s0960-894x(01)00170-6 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine