Assay Detail
Functional
CHEMBL702040
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Inhibition of ADP-induced aggregation of human platelets
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Inhibitors of blood platelet cAMP phosphodiesterase. 3. 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives with enhanced aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 56 | 5.89 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88787 | — | — | 1 | 7.33 |
| CHEMBL92205 | — | — | 1 | 7.30 |
| CHEMBL327234 | — | — | 1 | 7.29 |
| CHEMBL329173 | — | — | 1 | 7.27 |
| CHEMBL90380 | — | — | 1 | 7.21 |
| CHEMBL91503 | — | — | 1 | 6.96 |
| CHEMBL90647 | — | — | 1 | 6.89 |
| CHEMBL330737 | — | — | 1 | 6.77 |
| CHEMBL93730 | — | — | 1 | 6.72 |
| CHEMBL329248 | — | — | 1 | 6.60 |
| CHEMBL328543 | — | — | 1 | 6.57 |
| CHEMBL89276 | — | — | 1 | 6.55 |
| CHEMBL90877 | — | — | 1 | 6.54 |
| CHEMBL91014 | — | — | 1 | 6.48 |
| CHEMBL330086 | — | — | 1 | 6.42 |
| CHEMBL90876 | — | — | 1 | 6.42 |
| CHEMBL313021 | — | — | 1 | 6.37 |
| CHEMBL432057 | — | — | 1 | 6.29 |
| CHEMBL90546 | — | — | 1 | 6.28 |
| CHEMBL327882 | — | — | 1 | 6.28 |
| CHEMBL329788 | — | — | 1 | 6.17 |
| CHEMBL89820 | — | — | 1 | 6.17 |
| CHEMBL91715 | — | — | 1 | 6.15 |
| CHEMBL91088 | — | — | 1 | 6.14 |
| CHEMBL91249 | — | — | 1 | 6.12 |
| CHEMBL90183 | — | — | 1 | 6.05 |
| CHEMBL314949 | — | — | 1 | 6.04 |
| CHEMBL329412 | — | — | 1 | 5.91 |
| CHEMBL92165 | — | — | 1 | 5.89 |
| CHEMBL91720 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88787 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL92205 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL327234 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL329173 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL90380 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL91503 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL90647 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL330737 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL93730 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL329248 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL328543 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL89276 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL90877 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL91014 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL90876 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL330086 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL313021 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL432057 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL90546 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL327882 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL329788 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL89820 | — | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL91715 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL91088 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL91249 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL90183 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL314949 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL329412 | — | EC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL92165 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL91720 | — | EC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL329573 | — | EC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL329344 | — | EC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL91388 | — | EC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL89810 | — | EC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL90176 | — | EC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL89277 | — | EC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL431085 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL327808 | — | EC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL328711 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL330240 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL90849 | — | EC50 | = | 6820.0 | nM | 5.17 |
| CHEMBL327786 | — | EC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL279859 | — | EC50 | = | 8060.0 | nM | 5.09 |
| CHEMBL88797 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL91010 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL92169 | — | EC50 | = | 11350.0 | nM | 4.95 |
| CHEMBL90515 | — | EC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL92381 | — | EC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL90230 | — | EC50 | = | 20790.0 | nM | 4.68 |
| CHEMBL88182 | — | EC50 | = | 30250.0 | nM | 4.52 |