Assay Detail
Binding
CHEMBL702098
Review assay metadata, readout intent, target linkage, and publication context from the same page.
IC50 was measured as concentration required to inhibit 50% of HIV-integrase cleavage
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.62 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413552 | QUERCETAGETIN | — | 1 | 6.10 |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 5.92 |
| CHEMBL170405 | ROBINETIN | — | 1 | 5.23 |
| CHEMBL164 | MYRICETIN | — | 1 | 5.12 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.63 |
| CHEMBL31574 | FISETIN | 2.0 | 1 | 4.55 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 4.48 |
| CHEMBL1159644 | — | — | 1 | 4.40 |
| CHEMBL171315 | — | — | 1 | 4.22 |
| CHEMBL312163 | RHAMNETIN | — | 1 | 4.21 |
| CHEMBL353450 | — | — | 1 | 4.18 |
| CHEMBL2029094 | — | — | 1 | 4.16 |
| CHEMBL28626 | MORIN | — | 1 | 4.12 |
| CHEMBL172350 | EUPAFOLIN | — | 1 | 4.03 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413552 | QUERCETAGETIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL8260 | BAICALEIN | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL170405 | ROBINETIN | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL164 | MYRICETIN | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL50 | QUERCETIN | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL31574 | FISETIN | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL1159644 | — | IC50 | = | 39600.0 | nM | 4.40 |
| CHEMBL171315 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL312163 | RHAMNETIN | IC50 | = | 61600.0 | nM | 4.21 |
| CHEMBL353450 | — | IC50 | = | 66300.0 | nM | 4.18 |
| CHEMBL2029094 | — | IC50 | = | 69700.0 | nM | 4.16 |
| CHEMBL28626 | MORIN | IC50 | = | 76500.0 | nM | 4.12 |
| CHEMBL172350 | EUPAFOLIN | IC50 | = | 94300.0 | nM | 4.03 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 97800.0 | nM | 4.01 |