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Assay Detail

CHEMBL702126

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
In vitro cytotoxicity was evaluated against the L1210 Murine leukemic cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Intermediate

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis, cytotoxicity, and antiviral activity of some acyclic analogues of the pyrrolo[2,3-d]pyrimidine nucleoside antibiotics tubercidin, toyocamycin, and sangivamycin.
Gupta PK, Daunert S, Nassiri MR, Wotring LL, Drach JC, Townsend LB.
J Med Chem (1989) 32 : 402 -408
PubMed 2913300 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 8.11 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL101892 SANGIVAMYCIN 1 8.52
CHEMBL99668 TOYOCAMYCIN 1 8.40
CHEMBL267099 TUBERCIDIN 1 7.40
CHEMBL336797 1 -
CHEMBL300485 1 -
CHEMBL50879 1 -
CHEMBL51484 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL101892 SANGIVAMYCIN IC50 = 3.0 nM 8.52
CHEMBL99668 TOYOCAMYCIN IC50 = 4.0 nM 8.40
CHEMBL267099 TUBERCIDIN IC50 = 40.0 nM 7.40
CHEMBL336797 IC50 > 100000.0 nM -
CHEMBL300485 IC50 > 100000.0 nM -
CHEMBL50879 IC50 > 100000.0 nM -
CHEMBL51484 IC50 > 100000.0 nM -