Assay Detail
Functional
CHEMBL702317
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit lipopolysaccharide (LPS) induced PGE-2 production was determined by human whole blood assay.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.66 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325755 | — | — | 1 | 6.70 |
| CHEMBL107600 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325755 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL107600 | — | IC50 | = | 240.0 | nM | 6.62 |