Assay Detail
Functional
CHEMBL702326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for in vitro inhibition of leukotriene (LTB4) in human whole blood (HWB)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.03 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22789 | — | — | 1 | 7.44 |
| CHEMBL278293 | — | — | 1 | 7.38 |
| CHEMBL417464 | — | — | 1 | 7.33 |
| CHEMBL22736 | — | — | 1 | 7.05 |
| CHEMBL22751 | — | — | 1 | 6.99 |
| CHEMBL23007 | — | — | 1 | 6.80 |
| CHEMBL280348 | — | — | 1 | 6.71 |
| CHEMBL22578 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22789 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL278293 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL417464 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL22736 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL22751 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL23007 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL280348 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL22578 | — | IC50 | = | 287.0 | nM | 6.54 |