Assay Detail
Functional
CHEMBL702328
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for production of leukotriene B4 in human whole blood (HWB) activated with ionophore A-23187.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.94 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99469 | — | — | 1 | 8.00 |
| CHEMBL99217 | — | — | 1 | 7.52 |
| CHEMBL278293 | — | — | 1 | 7.38 |
| CHEMBL99942 | — | — | 1 | 7.30 |
| CHEMBL95470 | — | — | 1 | 7.17 |
| CHEMBL316641 | — | — | 1 | 7.00 |
| CHEMBL97380 | — | — | 1 | 6.82 |
| CHEMBL97923 | — | — | 1 | 6.60 |
| CHEMBL418775 | — | — | 1 | 6.52 |
| CHEMBL16596 | QUIFLAPON | 2.0 | 1 | 6.30 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99469 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL99217 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL278293 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL99942 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL95470 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL316641 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL97380 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL97923 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL418775 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL16596 | QUIFLAPON | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL93 | ZILEUTON | IC50 | = | 2000.0 | nM | 5.70 |