Assay Detail
Functional
CHEMBL702336
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Ability to inhibit LPS-induced TNF-alpha formation in human whole blood (HWB)
17
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Substituted 2-pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.24 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61191 | — | — | 4 | 6.96 |
| CHEMBL57524 | — | — | 1 | 6.80 |
| CHEMBL301441 | — | — | 1 | 6.52 |
| CHEMBL57131 | — | — | 1 | 6.47 |
| CHEMBL56330 | — | — | 1 | 6.44 |
| CHEMBL294717 | — | — | 1 | 6.43 |
| CHEMBL56971 | — | — | 1 | 6.34 |
| CHEMBL56575 | — | — | 1 | 6.31 |
| CHEMBL299931 | — | — | 1 | 6.26 |
| CHEMBL57095 | — | — | 1 | 6.22 |
| CHEMBL57757 | — | — | 1 | 6.11 |
| CHEMBL417776 | — | — | 1 | 6.05 |
| CHEMBL57767 | — | — | 1 | 5.66 |
| CHEMBL32442 | CDP840 | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61191 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL57524 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL61191 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL301441 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL57131 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL61191 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL56330 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL294717 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL56971 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL56575 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL299931 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL57095 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL57757 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL417776 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL57767 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL61191 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL32442 | CDP840 | IC50 | = | 16000.0 | nM | 4.80 |