Assay Detail
Functional
CHEMBL702339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of platelet aggregation by measuring its effect on the ADP-stimulated aggregation of human platelets
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.19 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315065 | — | — | 1 | 8.05 |
| CHEMBL1704 | — | — | 1 | 7.82 |
| CHEMBL118749 | — | — | 1 | 7.43 |
| CHEMBL117985 | — | — | 1 | 7.37 |
| CHEMBL145645 | — | — | 1 | 7.21 |
| CHEMBL144573 | — | — | 1 | 7.17 |
| CHEMBL144596 | — | — | 1 | 7.13 |
| CHEMBL344594 | — | — | 1 | 7.00 |
| CHEMBL142152 | — | — | 1 | 6.85 |
| CHEMBL435486 | — | — | 1 | 6.80 |
| CHEMBL142797 | — | — | 1 | 6.80 |
| CHEMBL143889 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315065 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1704 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL118749 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL117985 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL145645 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL144573 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL144596 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL344594 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL142152 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL435486 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL142797 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL143889 | — | IC50 | = | 210.0 | nM | 6.68 |