Assay Detail
Binding
CHEMBL702516
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Ionotropic glutamate receptor AMPA using [3H]AMPA as a radioligand
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic AMPA (CHEMBL2096670) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
(3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.88 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | 2.0 | 1 | 5.32 |
| CHEMBL308941 | — | — | 3 | 5.24 |
| CHEMBL72123 | — | — | 1 | 4.07 |
| CHEMBL144462 | — | — | 1 | - |
| CHEMBL423201 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL308941 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL308941 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL72123 | — | IC50 | = | 84500.0 | nM | 4.07 |
| CHEMBL308941 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL144462 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL423201 | — | IC50 | > | 100000.0 | nM | - |