Compound Detail
CHEMBL423201
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Basic Information
| ChEMBL ID | CHEMBL423201 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QXKNEWDFWPDNQH-XAVMHZPKSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
251.3
MW (Da)
0.15
ALogP
5
HBA
3
HBD
103.8
PSA (Ų)
0.69
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 4.42 | 4.42 | 38400.0 | 1 |
| Rattus norvegicus CHEMBL376 | IC50 | 4.19 | 4.19 | 65000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | IC50 | = | 38400.0 | nM | 4.42 | Binding affinity against NMDA receptor using [3H]-CGS- 19755 as a radioligand in... | 8523401 |
| Rattus norvegicus | IC50 | = | 65000.0 | nM | 4.19 | Inhibitory activity against compound induced depolarization of NMDA receptor in ... | 8523401 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8523401 | 10.1021/jm00025a005 | Rattus norvegicus | 3 |
| 8523401 | 10.1021/jm00025a005 | Glutamate NMDA receptor | 1 |
| 8523401 | 10.1021/jm00025a005 | Glutamate receptor ionotropic AMPA | 1 |
| 8523401 | 10.1021/jm00025a005 | Glutamate receptor ionotropic kainate | 1 |
Data from ChEMBL 36 via Core Engine