Assay Detail
Binding
CHEMBL745044
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Binding affinity against NMDA receptor using [3H]-CGS- 19755 as a radioligand in rat
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
(3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.38 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72123 | — | — | 1 | 6.09 |
| CHEMBL308941 | — | — | 3 | 6.00 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | 2.0 | 1 | 4.58 |
| CHEMBL423201 | — | — | 1 | 4.42 |
| CHEMBL144462 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72123 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL308941 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL308941 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL423201 | — | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL308941 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL144462 | — | IC50 | > | 100000.0 | nM | - |