Assay Detail
Functional
CHEMBL784315
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Inhibitory activity against compound induced depolarization of NMDA receptor in rat cortical slice preparation
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
(3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.95 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72123 | — | — | 1 | 5.85 |
| CHEMBL308941 | — | — | 3 | 5.39 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | 2.0 | 1 | 4.21 |
| CHEMBL423201 | — | — | 1 | 4.19 |
| CHEMBL144462 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72123 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL308941 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL308941 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | IC50 | = | 61300.0 | nM | 4.21 |
| CHEMBL423201 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL308941 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL144462 | — | IC50 | > | 100000.0 | nM | - |