Assay Detail
Binding
CHEMBL702518
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Compound was evaluated for its binding affinity towards Ionotropic glutamate receptor AMPA in presence of [3H]- AMPA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic AMPA (CHEMBL2096670) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Tricyclic quinoxalines as ligands for the strychnine-insensitive glycine site
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.79 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325124 | — | — | 1 | 5.16 |
| CHEMBL112386 | — | — | 1 | 5.10 |
| CHEMBL164669 | — | — | 1 | 4.68 |
| CHEMBL284028 | 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE | — | 1 | 4.57 |
| CHEMBL349413 | — | — | 1 | 4.44 |
| CHEMBL112014 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325124 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL112386 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL164669 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL284028 | 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL349413 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL112014 | — | IC50 | > | 100000.0 | nM | - |