Compound Detail
CHEMBL349413
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Basic Information
| ChEMBL ID | CHEMBL349413 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GCIXZVURAVDWTO-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
245.1
MW (Da)
1.53
ALogP
3
HBA
1
HBD
54.9
PSA (Ų)
0.72
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 CHEMBL330 | IC50 | 4.77 | 4.77 | 17000.0 | 1 |
| Glutamate receptor ionotropic AMPA CHEMBL2096670 | IC50 | 4.44 | 4.44 | 36000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | IC50 | = | 17000.0 | nM | 4.77 | Compound was evaluated for its binding affinity towards strychnine - insensitive... | - |
| Glutamate receptor ionotropic AMPA | IC50 | = | 36000.0 | nM | 4.44 | Compound was evaluated for its binding affinity towards Ionotropic glutamate rec... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)81062-3 | Glutamate receptor ionotropic, NMDA 1 | 1 |
| - | 10.1016/S0960-894X(01)81062-3 | Glutamate receptor ionotropic AMPA | 1 |
| - | 10.1016/S0960-894X(01)81062-3 | Glutamate receptor ionotropic, NMDA 2C | 1 |
Data from ChEMBL 36 via Core Engine