Assay Detail
Binding
CHEMBL748574
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Compound was evaluated for its binding affinity towards strychnine - insensitive glycine site of NMDA receptor in presence of [3H]- Gly
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Tricyclic quinoxalines as ligands for the strychnine-insensitive glycine site
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.78 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284028 | 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE | — | 1 | 5.40 |
| CHEMBL325124 | — | — | 1 | 5.22 |
| CHEMBL112386 | — | — | 1 | 5.16 |
| CHEMBL349413 | — | — | 1 | 4.77 |
| CHEMBL112014 | — | — | 1 | 4.11 |
| CHEMBL164669 | — | — | 1 | 4.02 |
| CHEMBL162708 | — | — | 1 | - |
| CHEMBL165324 | — | — | 1 | - |
| CHEMBL554030 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284028 | 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL325124 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL112386 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL349413 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL112014 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL164669 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL162708 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL165324 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL554030 | — | IC50 | > | 100000.0 | nM | - |