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Assay Detail

CHEMBL702708

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Binding
Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.
ChEMBL ↗
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Nitric oxide synthase, inducible (CHEMBL4481) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity.
Collins JL, Shearer BG, Oplinger JA, Lee S, Garvey EP, Salter M, Duffy C, Burnette TC, Furfine ES.
J Med Chem (1998) 41 : 2858 -2871
PubMed 9667974 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 50 5.54 7.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL555794 — — 1 7.68
CHEMBL555715 — — 1 6.92
CHEMBL544788 — — 1 6.85
CHEMBL552825 — — 1 6.80
CHEMBL555584 — — 1 6.32
CHEMBL227744 NITROARGININE 1.0 1 6.17
CHEMBL256147 TILARGININE 3.0 1 6.07
CHEMBL540048 — — 1 5.80
CHEMBL545025 — — 1 5.70
CHEMBL542432 — — 1 5.70
CHEMBL542678 — — 1 5.60
CHEMBL539793 — — 1 5.60
CHEMBL542675 — — 1 5.47
CHEMBL544317 — — 1 5.40
CHEMBL543142 — — 1 5.34
CHEMBL554201 — — 1 5.21
CHEMBL538021 — — 1 5.20
CHEMBL542676 — — 1 5.00
CHEMBL538767 — — 1 5.00
CHEMBL543380 — — 1 4.82
CHEMBL544090 — — 1 4.77
CHEMBL542433 — — 1 4.77
CHEMBL542912 — — 1 4.70
CHEMBL544793 — — 1 4.43
CHEMBL542674 — — 1 4.34
CHEMBL542429 — — 1 4.34
CHEMBL553453 — — 1 -
CHEMBL557337 — — 1 -
CHEMBL542910 — — 1 -
CHEMBL553132 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL555794 — Ki = 21.0 nM 7.68
CHEMBL555715 — Ki = 120.0 nM 6.92
CHEMBL544788 — Ki = 140.0 nM 6.85
CHEMBL552825 — Ki = 160.0 nM 6.80
CHEMBL555584 — Ki = 480.0 nM 6.32
CHEMBL227744 NITROARGININE Ki = 670.0 nM 6.17
CHEMBL256147 TILARGININE Ki = 860.0 nM 6.07
CHEMBL540048 — Ki = 1600.0 nM 5.80
CHEMBL545025 — Ki = 2000.0 nM 5.70
CHEMBL542432 — Ki = 2000.0 nM 5.70
CHEMBL542678 — Ki = 2500.0 nM 5.60
CHEMBL539793 — Ki = 2500.0 nM 5.60
CHEMBL542675 — Ki = 3400.0 nM 5.47
CHEMBL544317 — Ki = 4000.0 nM 5.40
CHEMBL543142 — Ki = 4600.0 nM 5.34
CHEMBL554201 — Ki = 6100.0 nM 5.21
CHEMBL538021 — Ki = 6300.0 nM 5.20
CHEMBL542676 — Ki = 10000.0 nM 5.00
CHEMBL538767 — Ki = 10000.0 nM 5.00
CHEMBL543380 — Ki = 15000.0 nM 4.82
CHEMBL544090 — Ki = 17000.0 nM 4.77
CHEMBL542433 — Ki = 17000.0 nM 4.77
CHEMBL542912 — Ki = 20000.0 nM 4.70
CHEMBL544793 — Ki = 37000.0 nM 4.43
CHEMBL542429 — Ki = 46000.0 nM 4.34
CHEMBL542674 — Ki = 46000.0 nM 4.34
CHEMBL544557 — Ki > 50000.0 nM -
CHEMBL540299 — Ki > 50000.0 nM -
CHEMBL542909 — Ki > 50000.0 nM -
CHEMBL554192 — Ki > 50000.0 nM -
CHEMBL545023 — Ki > 50000.0 nM -
CHEMBL544559 — Ki > 50000.0 nM -
CHEMBL543143 — Ki > 50000.0 nM -
CHEMBL540555 — Ki > 50000.0 nM -
CHEMBL542913 — Ki > 50000.0 nM -
CHEMBL555389 — Ki > 50000.0 nM -
CHEMBL545256 — Ki > 50000.0 nM -
CHEMBL539802 — Ki > 50000.0 nM -
CHEMBL554248 — Ki > 50000.0 nM -
CHEMBL544789 — Ki > 50000.0 nM -
CHEMBL542677 — Ki > 50000.0 nM -
CHEMBL544093 — Ki > 50000.0 nM -
CHEMBL540558 — Ki > 50000.0 nM -
CHEMBL542431 — Ki > 50000.0 nM -
CHEMBL544790 — Ki > 50000.0 nM -
CHEMBL543381 — Ki > 50000.0 nM -
CHEMBL553132 — Ki > 50000.0 nM -
CHEMBL542910 — Ki > 50000.0 nM -
CHEMBL557337 — Ki > 50000.0 nM -
CHEMBL553453 — Ki > 50000.0 nM -