Assay Detail
Binding
CHEMBL702710
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Inhibitory constant for the inhibition of human Inducible nitric oxide synthase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformationally restricted arginine analogues as inhibitors of human nitric oxide synthase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.27 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11471 | L-NIO | — | 1 | 6.47 |
| CHEMBL49881 | — | — | 1 | 6.22 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 6.07 |
| CHEMBL52280 | — | — | 1 | 5.72 |
| CHEMBL298404 | — | — | 1 | 5.58 |
| CHEMBL49010 | — | — | 1 | 4.09 |
| CHEMBL48861 | — | — | 1 | 4.02 |
| CHEMBL49934 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11471 | L-NIO | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL49881 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL256147 | TILARGININE | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL52280 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL298404 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL49010 | — | Ki | = | 82000.0 | nM | 4.09 |
| CHEMBL48861 | — | Ki | = | 96000.0 | nM | 4.02 |
| CHEMBL49934 | — | Ki | = | 100000.0 | nM | 4.00 |