Assay Detail
Functional
CHEMBL702820
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In vitro cytotoxicity against Human Chronic Leukemia K562 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Cross-linking and sequence specific alkylation of DNA BY aziridinylquinones. 1. Quinone methides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.20 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72536 | — | — | 1 | 8.05 |
| CHEMBL122013 | — | — | 1 | 7.00 |
| CHEMBL149909 | — | — | 1 | 6.22 |
| CHEMBL149866 | — | — | 1 | 6.22 |
| CHEMBL150457 | p-Xyloquinone | — | 1 | 6.12 |
| CHEMBL120194 | — | — | 1 | 5.92 |
| CHEMBL150643 | — | — | 1 | 5.90 |
| CHEMBL120541 | — | — | 1 | 5.89 |
| CHEMBL357033 | — | — | 1 | 5.85 |
| CHEMBL358225 | Cresoquinone | — | 1 | 5.56 |
| CHEMBL423039 | — | — | 1 | 5.44 |
| CHEMBL356836 | — | — | 1 | - |
| CHEMBL151040 | — | — | 1 | - |
| CHEMBL150888 | — | — | 1 | - |
| CHEMBL150244 | — | — | 1 | - |
| CHEMBL151604 | DUROQUINONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72536 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL122013 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL149909 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL149866 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL150457 | p-Xyloquinone | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL120194 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL150643 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL120541 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL357033 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL358225 | Cresoquinone | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL423039 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL356836 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL151040 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL150888 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL150244 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL151604 | DUROQUINONE | IC50 | > | 50000.0 | nM | - |