Assay Detail
Functional
CHEMBL702841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration for doubling of partial thromboplastin time
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.33 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107392 | — | — | 1 | 6.58 |
| CHEMBL322901 | — | — | 1 | 6.55 |
| CHEMBL322165 | — | — | 1 | 6.46 |
| CHEMBL107627 | — | — | 1 | 6.41 |
| CHEMBL1166 | ARGATROBAN | 4.0 | 1 | 6.38 |
| CHEMBL51173 | — | — | 1 | 6.30 |
| CHEMBL107282 | — | — | 1 | 6.25 |
| CHEMBL104731 | — | — | 1 | 6.16 |
| CHEMBL107911 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107392 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL322901 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL322165 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL107627 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1166 | ARGATROBAN | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL51173 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL107282 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL104731 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL107911 | — | IC50 | = | 1200.0 | nM | 5.92 |