Assay Detail
Functional
CHEMBL702843
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Concentration for doubling of thrombin time
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.10 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107392 | — | — | 1 | 7.43 |
| CHEMBL107627 | — | — | 1 | 7.38 |
| CHEMBL51173 | — | — | 1 | 7.35 |
| CHEMBL322901 | — | — | 1 | 7.21 |
| CHEMBL1166 | ARGATROBAN | 4.0 | 1 | 7.21 |
| CHEMBL322165 | — | — | 1 | 7.20 |
| CHEMBL107282 | — | — | 1 | 6.85 |
| CHEMBL107911 | — | — | 1 | 6.66 |
| CHEMBL104731 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107392 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL107627 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL51173 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL322901 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1166 | ARGATROBAN | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL322165 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL107282 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL107911 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL104731 | — | IC50 | = | 240.0 | nM | 6.62 |