Assay Detail
Functional
CHEMBL702845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of thrombin-activatable fibrinolysis was determined by clot lysis assay using human plasma
13
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.41 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68399 | — | — | 2 | 8.70 |
| CHEMBL149680 | — | — | 1 | 8.10 |
| CHEMBL436425 | — | — | 1 | 7.55 |
| CHEMBL302067 | — | — | 3 | 7.40 |
| CHEMBL344949 | — | — | 1 | 7.38 |
| CHEMBL358017 | — | — | 1 | 7.32 |
| CHEMBL356252 | — | — | 1 | 7.16 |
| CHEMBL150332 | — | — | 1 | 6.70 |
| CHEMBL151284 | — | — | 1 | - |
| CHEMBL33352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68399 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL68399 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL149680 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL436425 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL302067 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL344949 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL358017 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL356252 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL302067 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL150332 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL302067 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL151284 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL33352 | — | IC50 | > | 100000.0 | nM | - |