Assay Detail
Functional
CHEMBL702850
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Plasma equilibrium dissociation constant was determined
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 5.21 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99235 | — | — | 1 | 6.12 |
| CHEMBL329720 | — | — | 1 | 5.92 |
| CHEMBL177016 | — | — | 1 | 5.61 |
| CHEMBL171920 | — | — | 1 | 5.38 |
| CHEMBL367052 | — | — | 1 | 5.09 |
| CHEMBL176972 | — | — | 1 | 4.75 |
| CHEMBL177271 | — | — | 1 | 4.74 |
| CHEMBL83622 | — | — | 1 | 4.67 |
| CHEMBL176362 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99235 | — | Kd | = | 760.0 | nM | 6.12 |
| CHEMBL329720 | — | Kd | = | 1210.0 | nM | 5.92 |
| CHEMBL177016 | — | Kd | = | 2450.0 | nM | 5.61 |
| CHEMBL171920 | — | Kd | = | 4160.0 | nM | 5.38 |
| CHEMBL367052 | — | Kd | = | 8160.0 | nM | 5.09 |
| CHEMBL176972 | — | Kd | = | 17600.0 | nM | 4.75 |
| CHEMBL177271 | — | Kd | = | 18200.0 | nM | 4.74 |
| CHEMBL83622 | — | Kd | = | 21600.0 | nM | 4.67 |
| CHEMBL176362 | — | Kd | = | 24000.0 | nM | 4.62 |