Assay Detail
Binding
CHEMBL702865
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In vitro binding affinity against Ionotropic glutamate receptor kainate (kainic acid) using [3H]KAIN as radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic kainate (CHEMBL2109241) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Heteroaryl analogues of AMPA. Synthesis and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.51 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310897 | — | — | 1 | 5.31 |
| CHEMBL328310 | — | — | 1 | 4.80 |
| CHEMBL94859 | — | — | 1 | 4.39 |
| CHEMBL318467 | — | — | 1 | 4.24 |
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 4.17 |
| CHEMBL98723 | — | — | 1 | 4.13 |
| CHEMBL317790 | — | — | 1 | - |
| CHEMBL97742 | — | — | 1 | - |
| CHEMBL94860 | — | — | 1 | - |
| CHEMBL441460 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310897 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL328310 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL94859 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL318467 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL13378 | (R,S)-AMPA | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL98723 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL317790 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL97742 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL94860 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL441460 | — | IC50 | > | 100000.0 | nM | - |