Assay Detail
Binding
CHEMBL702875
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Displacement of [3H]CNQX from Ionotropic glutamate receptor kainate/Ionotropic glutamate receptor AMPA in rat cortical membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and glutamate antagonist activity of 4-phosphonoalkylquinoline derivatives: A novel class of non-NMDA antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.80 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9790 | — | — | 1 | 6.89 |
| CHEMBL284012 | — | — | 1 | 5.14 |
| CHEMBL64417 | — | — | 1 | 4.82 |
| CHEMBL61550 | — | — | 1 | 4.58 |
| CHEMBL64819 | — | — | 1 | 4.46 |
| CHEMBL294796 | — | — | 1 | 4.23 |
| CHEMBL63386 | — | — | 1 | 4.21 |
| CHEMBL432901 | — | — | 1 | 4.04 |
| CHEMBL62849 | — | — | 1 | - |
| CHEMBL62372 | — | — | 1 | - |
| CHEMBL292600 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9790 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL284012 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL64417 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL61550 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL64819 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL294796 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL63386 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL432901 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL62849 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL62372 | — | IC50 | = | 384000.0 | nM | - |
| CHEMBL292600 | — | IC50 | > | 1000000.0 | nM | - |