Compound Detail
CHEMBL432901
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Basic Information
| ChEMBL ID | CHEMBL432901 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DYEVQTFADZESQP-UHFFFAOYSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
287.6
MW (Da)
2.31
ALogP
3
HBA
3
HBD
90.7
PSA (Ų)
0.75
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.04
Ki 1 meas. best 4.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rattus norvegicus CHEMBL376 | Ki | 4.29 | 4.29 | 51000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.04 | 4.04 | 91000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | Ki | = | 51000.0 | nM | 4.29 | Compound was tested for the ability to inhibit kainic acid (KA)-induced inward c... | - |
| Unchecked | IC50 | = | 91000.0 | nM | 4.04 | Displacement of [3H]CNQX from Ionotropic glutamate receptor kainate/Ionotropic g... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)80558-8 | Unchecked | 2 |
| - | 10.1016/S0960-894X(01)80558-8 | Rattus norvegicus | 1 |
| - | 10.1016/S0960-894X(01)80558-8 | Glutamate receptor ionotropic, NMDA 1 | 1 |
Data from ChEMBL 36 via Core Engine