Assay Detail
Functional
CHEMBL789201
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the ability to inhibit kainic acid (KA)-induced inward currents in Xenopus oocytes injected with poly {A+) mRNA from rats
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and glutamate antagonist activity of 4-phosphonoalkylquinoline derivatives: A novel class of non-NMDA antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.67 | 5.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64417 | — | — | 1 | 5.02 |
| CHEMBL64819 | — | — | 1 | 4.81 |
| CHEMBL61550 | — | — | 1 | 4.74 |
| CHEMBL294796 | — | — | 1 | 4.50 |
| CHEMBL432901 | — | — | 1 | 4.29 |
| CHEMBL62849 | — | — | 1 | - |
| CHEMBL305312 | — | — | 1 | - |
| CHEMBL62372 | — | — | 1 | - |
| CHEMBL63386 | — | — | 1 | - |
| CHEMBL292600 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64417 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL64819 | — | Ki | = | 15600.0 | nM | 4.81 |
| CHEMBL61550 | — | Ki | = | 18200.0 | nM | 4.74 |
| CHEMBL294796 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL432901 | — | Ki | = | 51000.0 | nM | 4.29 |
| CHEMBL62849 | — | Ki | = | 379000.0 | nM | - |
| CHEMBL305312 | — | Ki | >> | 1000000.0 | nM | - |
| CHEMBL62372 | — | Ki | = | 450000.0 | nM | - |
| CHEMBL63386 | — | Ki | = | 132000.0 | nM | - |
| CHEMBL292600 | — | Ki | > | 300000.0 | nM | - |