Assay Detail
Binding
CHEMBL702887
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of inducible nitric oxide synthase (iNOS) in mice
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.38 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105792 | — | — | 1 | 8.52 |
| CHEMBL108318 | — | — | 1 | 7.39 |
| CHEMBL105820 | — | — | 1 | 7.25 |
| CHEMBL107413 | — | — | 1 | 7.13 |
| CHEMBL317459 | — | — | 1 | 6.92 |
| CHEMBL110705 | — | — | 1 | 6.92 |
| CHEMBL106261 | — | — | 1 | 6.92 |
| CHEMBL108319 | — | — | 1 | 6.89 |
| CHEMBL110789 | — | — | 1 | 6.82 |
| CHEMBL323117 | — | — | 1 | 6.80 |
| CHEMBL105830 | — | — | 1 | 6.77 |
| CHEMBL107404 | — | — | 1 | 6.64 |
| CHEMBL108352 | — | — | 1 | 6.55 |
| CHEMBL320547 | — | — | 1 | 6.30 |
| CHEMBL447832 | — | — | 1 | 6.30 |
| CHEMBL105823 | — | — | 1 | 5.82 |
| CHEMBL108788 | — | — | 1 | 5.80 |
| CHEMBL110498 | — | — | 1 | 5.60 |
| CHEMBL322085 | — | — | 1 | 5.17 |
| CHEMBL69446 | — | — | 1 | 5.10 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 4.72 |
| CHEMBL227744 | NITROARGININE | 1.0 | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105792 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL108318 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL105820 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL107413 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL317459 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL110705 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL106261 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL108319 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL110789 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL323117 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL105830 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL107404 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL108352 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL320547 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL447832 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL105823 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL108788 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL110498 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL322085 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL69446 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL256147 | TILARGININE | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL227744 | NITROARGININE | IC50 | = | 80000.0 | nM | 4.10 |