Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL703063

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition against human KYSE-70 cell lines
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KYSE-70
Confidence 1 — Organism
Curated By Expert

Target

KYSE-70 cell line (CHEMBL614012)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, X-ray crystal structures, stabilities, and in vitro cytotoxic activities of new heteroarylacrylonitriles.
Saczewski F, Reszka P, Gdaniec M, Grünert R, Bednarski PJ.
J Med Chem (2004) 47 : 3438 -3449
PubMed 15189040 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.88 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL440896 1 6.80
CHEMBL323906 1 6.46
CHEMBL116696 1 6.40
CHEMBL331583 1 6.38
CHEMBL430890 1 6.36
CHEMBL117966 1 6.35
CHEMBL117076 1 6.18
CHEMBL44657 ETOPOSIDE 4.0 1 6.10
CHEMBL113815 1 5.93
CHEMBL11359 CISPLATIN 4.0 1 5.83
CHEMBL117195 1 5.60
CHEMBL117536 1 5.29
CHEMBL116569 1 5.06
CHEMBL118079 1 4.81
CHEMBL114935 1 4.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL440896 IC50 = 160.0 nM 6.80
CHEMBL323906 IC50 = 350.0 nM 6.46
CHEMBL116696 IC50 = 400.0 nM 6.40
CHEMBL331583 IC50 = 420.0 nM 6.38
CHEMBL430890 IC50 = 440.0 nM 6.36
CHEMBL117966 IC50 = 450.0 nM 6.35
CHEMBL117076 IC50 = 660.0 nM 6.18
CHEMBL44657 ETOPOSIDE IC50 = 790.0 nM 6.10
CHEMBL113815 IC50 = 1170.0 nM 5.93
CHEMBL11359 CISPLATIN IC50 = 1490.0 nM 5.83
CHEMBL117195 IC50 = 2530.0 nM 5.60
CHEMBL117536 IC50 = 5110.0 nM 5.29
CHEMBL116569 IC50 = 8780.0 nM 5.06
CHEMBL118079 IC50 = 15640.0 nM 4.81
CHEMBL114935 IC50 = 22530.0 nM 4.65