Assay Detail
Functional
CHEMBL703140
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In vitro vasorelaxing effect evoked on endothelium-denuded rat aortic rings in the presence of 1 uM glibenclamide
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Highly potent 1,4-benzothiazine derivatives as K(ATP)-channel openers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.69 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121181 | — | — | 1 | 7.16 |
| CHEMBL123534 | — | — | 1 | 7.03 |
| CHEMBL123939 | — | — | 1 | 6.52 |
| CHEMBL333739 | — | — | 1 | 6.38 |
| CHEMBL121402 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121181 | — | IC50 | = | 69.18 | nM | 7.16 |
| CHEMBL123534 | — | IC50 | = | 93.33 | nM | 7.03 |
| CHEMBL123939 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL333739 | — | IC50 | = | 416.87 | nM | 6.38 |
| CHEMBL121402 | — | IC50 | = | 436.52 | nM | 6.36 |