Assay Detail
Functional
CHEMBL703373
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Concentration that inhibits the proliferation of L1210 cells by 50%
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.69 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL164269 | — | — | 1 | 7.85 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.85 |
| CHEMBL163627 | — | — | 1 | 7.04 |
| CHEMBL413338 | — | — | 1 | 7.03 |
| CHEMBL430750 | — | — | 1 | 6.41 |
| CHEMBL71339 | — | — | 1 | 6.23 |
| CHEMBL348800 | — | — | 1 | 5.57 |
| CHEMBL162486 | — | — | 1 | 5.54 |
| CHEMBL349214 | — | — | 1 | - |
| CHEMBL415745 | — | — | 1 | - |
| CHEMBL350071 | — | — | 1 | - |
| CHEMBL163256 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL164269 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL163627 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL413338 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL430750 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL71339 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL348800 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL162486 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL349214 | — | IC50 | > | 5900.0 | nM | - |
| CHEMBL415745 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL350071 | — | IC50 | > | 5900.0 | nM | - |
| CHEMBL163256 | — | IC50 | > | 5900.0 | nM | - |