Compound Detail
CHEMBL71339
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Basic Information
| ChEMBL ID | CHEMBL71339 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PEZXVOHRDBYBFR-CYBMUJFWSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
332.4
MW (Da)
2.98
ALogP
5
HBA
0
HBD
61.2
PSA (Ų)
0.50
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.23
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| L1210 CHEMBL386 | IC50 | 6.23 | 6.23 | 590.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| L1210 | IC50 | = | 590.0 | nM | 6.23 | Concentration that inhibits the proliferation of L1210 cells by 50% | 2537428 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2537428 | 10.1021/jm00123a038 | DNA topoisomerase 1 | 1 |
| 2537428 | 10.1021/jm00123a038 | L1210 | 1 |
| 9632354 | 10.1021/jm9605445 | DNA topoisomerase 1 | 1 |
Data from ChEMBL 36 via Core Engine