Assay Detail
Functional
CHEMBL703444
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Inhibitory concentration against Murine Lewis lung carcinoma (LLC) cell proliferation
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Lewis lung carcinoma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor properties of N-[2-(dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: a new class of putative topoisomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.72 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 7.92 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.66 |
| CHEMBL64927 | — | — | 1 | 7.52 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.48 |
| CHEMBL303785 | — | — | 1 | 7.18 |
| CHEMBL64036 | — | — | 1 | 7.04 |
| CHEMBL62347 | — | — | 1 | 6.96 |
| CHEMBL65436 | — | — | 1 | 6.82 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.75 |
| CHEMBL293859 | — | — | 1 | 6.72 |
| CHEMBL9940 | — | — | 1 | 6.72 |
| CHEMBL60437 | — | — | 1 | 6.68 |
| CHEMBL62522 | — | — | 1 | 6.54 |
| CHEMBL64382 | — | — | 1 | 6.44 |
| CHEMBL63120 | — | — | 1 | 6.41 |
| CHEMBL418668 | — | — | 1 | 6.37 |
| CHEMBL60552 | — | — | 1 | 6.16 |
| CHEMBL62789 | — | — | 1 | 6.06 |
| CHEMBL62763 | — | — | 1 | 6.00 |
| CHEMBL291885 | — | — | 1 | 5.85 |
| CHEMBL62883 | — | — | 1 | 5.77 |
| CHEMBL64307 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43 | AMSACRINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL64927 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL303785 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL64036 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL62347 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL65436 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL293859 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL9940 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL60437 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL62522 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL64382 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL63120 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL418668 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL60552 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL62789 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL62763 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL291885 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL62883 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL64307 | — | IC50 | > | 2000.0 | nM | - |