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Assay Detail

CHEMBL703500

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration required for 50% inhibition of cell growth (L1210 Leukemia)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Optimization of the Schiff bases of N-hydroxy-N'-aminoguanidine as anticancer and antiviral agents.
T'ang A, Lien EJ, Lai MM.
J Med Chem (1985) 28 : 1103 -1106
PubMed 2991520 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.98 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL274679 1 5.57
CHEMBL12991 1 5.48
CHEMBL12899 1 5.17
CHEMBL12724 1 5.15
CHEMBL274884 1 5.12
CHEMBL13274 1 5.04
CHEMBL12869 1 5.03
CHEMBL13261 1 4.97
CHEMBL13277 1 4.90
CHEMBL274424 1 4.83
CHEMBL12571 HYDROXYGUANIDINE SULPHATE 1 4.78
CHEMBL12964 1 4.78
CHEMBL467 HYDROXYUREA 4.0 1 4.67
CHEMBL12586 1 4.64
CHEMBL12481 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL274679 IC50 = 2691.53 nM 5.57
CHEMBL12991 IC50 = 3311.31 nM 5.48
CHEMBL12899 IC50 = 6760.83 nM 5.17
CHEMBL12724 IC50 = 7079.46 nM 5.15
CHEMBL274884 IC50 = 7585.78 nM 5.12
CHEMBL13274 IC50 = 9120.11 nM 5.04
CHEMBL12869 IC50 = 9332.54 nM 5.03
CHEMBL13261 IC50 = 10715.19 nM 4.97
CHEMBL13277 IC50 = 12589.25 nM 4.90
CHEMBL274424 IC50 = 14791.08 nM 4.83
CHEMBL12571 HYDROXYGUANIDINE SULPHATE IC50 = 16595.87 nM 4.78
CHEMBL12964 IC50 = 16595.87 nM 4.78
CHEMBL467 HYDROXYUREA IC50 = 21379.62 nM 4.67
CHEMBL12586 IC50 = 22908.68 nM 4.64
CHEMBL12481 IC50 = 25118.86 nM 4.60