Assay Detail
Binding
CHEMBL703580
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Binding affinity against human plasma kallikrein.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.77 | 6.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111567 | — | — | 1 | 6.95 |
| CHEMBL108447 | — | — | 1 | 6.84 |
| CHEMBL442201 | — | — | 1 | 6.64 |
| CHEMBL111338 | — | — | 1 | 6.40 |
| CHEMBL109367 | — | — | 1 | 6.36 |
| CHEMBL323387 | — | — | 1 | 6.07 |
| CHEMBL109535 | — | — | 1 | 5.87 |
| CHEMBL111471 | — | — | 1 | 5.86 |
| CHEMBL320749 | — | — | 1 | 5.61 |
| CHEMBL104937 | — | — | 1 | 5.60 |
| CHEMBL111432 | — | — | 1 | 5.59 |
| CHEMBL111575 | — | — | 1 | 5.57 |
| CHEMBL418839 | — | — | 1 | 5.48 |
| CHEMBL111543 | — | — | 1 | 5.37 |
| CHEMBL324168 | — | — | 1 | 5.14 |
| CHEMBL109287 | — | — | 1 | 5.10 |
| CHEMBL111660 | — | — | 1 | 4.74 |
| CHEMBL105171 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111567 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL108447 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL442201 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL111338 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL109367 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL323387 | — | Ki | = | 849.0 | nM | 6.07 |
| CHEMBL109535 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL111471 | — | Ki | = | 1370.0 | nM | 5.86 |
| CHEMBL320749 | — | Ki | = | 2430.0 | nM | 5.61 |
| CHEMBL104937 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL111432 | — | Ki | = | 2570.0 | nM | 5.59 |
| CHEMBL111575 | — | Ki | = | 2720.0 | nM | 5.57 |
| CHEMBL418839 | — | Ki | = | 3330.0 | nM | 5.48 |
| CHEMBL111543 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL324168 | — | Ki | = | 7170.0 | nM | 5.14 |
| CHEMBL109287 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL111660 | — | Ki | = | 18100.0 | nM | 4.74 |
| CHEMBL105171 | — | Ki | = | 22500.0 | nM | 4.65 |