Assay Detail
Binding
CHEMBL703581
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Inhibitory activity against Kallikrein (PK)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.70 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322165 | — | — | 1 | 5.48 |
| CHEMBL107627 | — | — | 1 | 5.14 |
| CHEMBL322901 | — | — | 1 | 4.82 |
| CHEMBL319035 | — | — | 1 | 4.66 |
| CHEMBL107282 | — | — | 1 | 4.57 |
| CHEMBL107392 | — | — | 1 | 4.24 |
| CHEMBL107743 | — | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322165 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL107627 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL322901 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL319035 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL107282 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL107392 | — | Ki | = | 58000.0 | nM | 4.24 |
| CHEMBL107743 | — | Ki | = | 97000.0 | nM | 4.01 |