Assay Detail
Binding
CHEMBL703974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H](+)-PN200-110 binding to calcium channels of GH4C1 cells under depolarized conditions (50 mM K+).
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | GH4-C1 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated L-type calcium channel (CHEMBL2095177) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Permanently charged chiral 1,4-dihydropyridines: molecular probes of L-type calcium channels. Synthesis and pharmacological characterization of methyl(omega-trimethylalkylammonium) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate iodide, calcium channel antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.07 | 6.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL609700 | — | — | 1 | 6.61 |
| CHEMBL2051962 | — | — | 1 | 6.19 |
| CHEMBL2111604 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL609700 | — | Ki | = | 248.5 | nM | 6.61 |
| CHEMBL2051962 | — | Ki | = | 651.0 | nM | 6.19 |
| CHEMBL2111604 | — | Ki | = | 3988.0 | nM | 5.40 |