Assay Detail
Binding
CHEMBL703977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Voltage-dependent L-type calcium channel subunit alpha-1D (CHEMBL4132) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.61 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277363 | — | — | 1 | 9.37 |
| CHEMBL24662 | — | — | 1 | 9.11 |
| CHEMBL278804 | — | — | 1 | 8.48 |
| CHEMBL25512 | — | — | 1 | 8.36 |
| CHEMBL24998 | — | — | 1 | 7.92 |
| CHEMBL18988 | — | — | 1 | 7.82 |
| CHEMBL25278 | — | — | 1 | 7.66 |
| CHEMBL284195 | — | — | 1 | 7.54 |
| CHEMBL282348 | — | — | 1 | 7.52 |
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 7.34 |
| CHEMBL24675 | — | — | 1 | 7.28 |
| CHEMBL282651 | — | — | 1 | 7.19 |
| CHEMBL24086 | — | — | 1 | 7.09 |
| CHEMBL26172 | — | — | 1 | 6.97 |
| CHEMBL283615 | — | — | 1 | 6.87 |
| CHEMBL275195 | — | — | 1 | 6.82 |
| CHEMBL282989 | — | — | 1 | 6.70 |
| CHEMBL24085 | — | — | 1 | 6.66 |
| CHEMBL25124 | — | — | 1 | 6.52 |
| CHEMBL278171 | — | — | 1 | 6.50 |
| CHEMBL277293 | — | — | 1 | 6.50 |
| CHEMBL287410 | — | — | 1 | 6.40 |
| CHEMBL26495 | — | — | 1 | 6.33 |
| CHEMBL287054 | — | — | 1 | 6.11 |
| CHEMBL24529 | — | — | 1 | 5.91 |
| CHEMBL281762 | — | — | 1 | 5.91 |
| CHEMBL280391 | — | — | 1 | 5.80 |
| CHEMBL282854 | — | — | 1 | 5.80 |
| CHEMBL24243 | — | — | 1 | 5.69 |
| CHEMBL279886 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277363 | — | IC50 | = | 0.4266 | nM | 9.37 |
| CHEMBL24662 | — | IC50 | = | 0.7762 | nM | 9.11 |
| CHEMBL278804 | — | IC50 | = | 3.311 | nM | 8.48 |
| CHEMBL25512 | — | IC50 | = | 4.365 | nM | 8.36 |
| CHEMBL24998 | — | IC50 | = | 12.02 | nM | 7.92 |
| CHEMBL18988 | — | IC50 | = | 15.14 | nM | 7.82 |
| CHEMBL25278 | — | IC50 | = | 21.88 | nM | 7.66 |
| CHEMBL284195 | — | IC50 | = | 28.84 | nM | 7.54 |
| CHEMBL282348 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL23 | DILTIAZEM | IC50 | = | 45.71 | nM | 7.34 |
| CHEMBL24675 | — | IC50 | = | 52.48 | nM | 7.28 |
| CHEMBL282651 | — | IC50 | = | 64.57 | nM | 7.19 |
| CHEMBL24086 | — | IC50 | = | 81.28 | nM | 7.09 |
| CHEMBL26172 | — | IC50 | = | 107.15 | nM | 6.97 |
| CHEMBL283615 | — | IC50 | = | 134.9 | nM | 6.87 |
| CHEMBL275195 | — | IC50 | = | 151.36 | nM | 6.82 |
| CHEMBL282989 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL24085 | — | IC50 | = | 218.78 | nM | 6.66 |
| CHEMBL25124 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL278171 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL277293 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL287410 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL26495 | — | IC50 | = | 467.74 | nM | 6.33 |
| CHEMBL287054 | — | IC50 | = | 776.25 | nM | 6.11 |
| CHEMBL24529 | — | IC50 | = | 1230.27 | nM | 5.91 |
| CHEMBL281762 | — | IC50 | = | 1230.27 | nM | 5.91 |
| CHEMBL280391 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL282854 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL24243 | — | IC50 | = | 2041.74 | nM | 5.69 |
| CHEMBL279886 | — | IC50 | = | 2187.76 | nM | 5.66 |
| CHEMBL26442 | — | IC50 | = | 4365.16 | nM | 5.36 |
| CHEMBL26605 | — | IC50 | = | 4677.35 | nM | 5.33 |
| CHEMBL429774 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL442147 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL26239 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL281664 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL24620 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL281311 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL283244 | — | IC50 | = | 5011.87 | nM | 5.30 |