Assay Detail
Binding
CHEMBL704369
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LTB4 receptor binding from radioligand binding assay using guinea pig spleen cell membrane
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Spleen |
| Cell Type | spleen |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Structure-activity relationships study of two series of leukotriene B4 antagonists: novel indolyl and naphthyl compounds substituted with a 2-[methyl(2-phenethyl)amino]-2-oxoethyl side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 8.59 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328712 | — | — | 1 | 9.44 |
| CHEMBL125723 | — | — | 1 | 9.35 |
| CHEMBL125646 | — | — | 1 | 9.24 |
| CHEMBL126200 | — | — | 1 | 9.22 |
| CHEMBL125214 | — | — | 1 | 9.10 |
| CHEMBL341116 | — | — | 1 | 9.00 |
| CHEMBL333493 | — | — | 1 | 9.00 |
| CHEMBL125559 | — | — | 1 | 9.00 |
| CHEMBL123486 | — | — | 1 | 8.97 |
| CHEMBL122852 | — | — | 1 | 8.89 |
| CHEMBL3706723 | — | — | 1 | 8.84 |
| CHEMBL332813 | — | — | 1 | 8.82 |
| CHEMBL419419 | — | — | 1 | 8.82 |
| CHEMBL127340 | — | — | 1 | 8.82 |
| CHEMBL341360 | — | — | 1 | 8.82 |
| CHEMBL125476 | — | — | 1 | 8.70 |
| CHEMBL127818 | — | — | 1 | 8.63 |
| CHEMBL126053 | — | — | 1 | 8.60 |
| CHEMBL125117 | — | — | 1 | 8.60 |
| CHEMBL125128 | — | — | 1 | 8.55 |
| CHEMBL333079 | — | — | 1 | 8.52 |
| CHEMBL122134 | — | — | 1 | 8.46 |
| CHEMBL125013 | — | — | 1 | 8.37 |
| CHEMBL123201 | — | — | 1 | 8.35 |
| CHEMBL122217 | — | — | 1 | 8.30 |
| CHEMBL125131 | — | — | 1 | 8.30 |
| CHEMBL121959 | — | — | 1 | 8.19 |
| CHEMBL122375 | — | — | 1 | 8.10 |
| CHEMBL122461 | — | — | 1 | 8.00 |
| CHEMBL340295 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328712 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL125723 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL125646 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL126200 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL125214 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL341116 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL333493 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL125559 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL123486 | — | IC50 | = | 1.07 | nM | 8.97 |
| CHEMBL122852 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3706723 | — | IC50 | = | 1.45 | nM | 8.84 |
| CHEMBL332813 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL419419 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL127340 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL341360 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL125476 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL127818 | — | IC50 | = | 2.33 | nM | 8.63 |
| CHEMBL125117 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL126053 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL125128 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL333079 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL122134 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL125013 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL123201 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL122217 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL125131 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL121959 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL122375 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL122461 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL340295 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL332348 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL124905 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL125981 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL333273 | — | IC50 | > | 30.0 | nM | - |
| CHEMBL332233 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL122094 | — | IC50 | > | 300.0 | nM | - |