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Assay Detail

CHEMBL704374

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Spleen
Subcellular Membrane
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Leukotriene B4 receptor 1 (CHEMBL3911)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

omega-[(4-Phenyl-2-quinolyl)oxy]alkanoic acid derivatives: a new family of potent LTB4 antagonists.
Labaudinière R, Hendel W, Terlain B, Cavy F, Marquis O, Dereu N.
J Med Chem (1992) 35 : 4306 -4314
PubMed 1333011 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 6.64 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL49302 1 8.70
CHEMBL136805 1 8.00
CHEMBL137497 1 7.82
CHEMBL137248 1 7.52
CHEMBL342688 1 7.52
CHEMBL137168 1 7.52
CHEMBL134697 1 7.40
CHEMBL134698 1 6.82
CHEMBL335525 1 6.74
CHEMBL138018 1 6.52
CHEMBL434810 1 6.52
CHEMBL137030 1 6.40
CHEMBL137234 1 6.30
CHEMBL137570 1 6.26
CHEMBL137625 1 6.16
CHEMBL345047 1 6.10
CHEMBL422282 1 5.96
CHEMBL136433 1 5.75
CHEMBL137676 1 5.70
CHEMBL335142 1 5.70
CHEMBL137654 1 5.60
CHEMBL137346 1 5.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL49302 IC50 = 2.0 nM 8.70
CHEMBL136805 IC50 = 10.0 nM 8.00
CHEMBL137497 IC50 = 15.0 nM 7.82
CHEMBL137248 IC50 = 30.0 nM 7.52
CHEMBL342688 IC50 = 30.0 nM 7.52
CHEMBL137168 IC50 = 30.0 nM 7.52
CHEMBL134697 IC50 = 40.0 nM 7.40
CHEMBL134698 IC50 = 150.0 nM 6.82
CHEMBL335525 IC50 = 183.0 nM 6.74
CHEMBL138018 IC50 = 300.0 nM 6.52
CHEMBL434810 IC50 = 300.0 nM 6.52
CHEMBL137030 IC50 = 400.0 nM 6.40
CHEMBL137234 IC50 = 500.0 nM 6.30
CHEMBL137570 IC50 = 550.0 nM 6.26
CHEMBL137625 IC50 = 700.0 nM 6.16
CHEMBL345047 IC50 = 800.0 nM 6.10
CHEMBL422282 IC50 = 1100.0 nM 5.96
CHEMBL136433 IC50 = 1800.0 nM 5.75
CHEMBL137676 IC50 = 2000.0 nM 5.70
CHEMBL335142 IC50 = 2000.0 nM 5.70
CHEMBL137654 IC50 = 2500.0 nM 5.60
CHEMBL137346 IC50 = 8000.0 nM 5.10