Assay Detail
Binding
CHEMBL704378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Spleen |
| Cell Type | spleen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthetic and structure/activity studies on acid-substituted 2-arylphenols: discovery of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]-propoxy]phenoxy]benzoic acid, a high-affinity leukotriene B4 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.63 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139969 | — | — | 1 | 8.23 |
| CHEMBL138954 | — | — | 1 | 7.60 |
| CHEMBL139115 | — | — | 1 | 7.48 |
| CHEMBL139799 | — | — | 1 | 7.44 |
| CHEMBL139254 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139969 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL138954 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL139115 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL139799 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL139254 | — | Ki | = | 42.0 | nM | 7.38 |