Assay Detail
Binding
CHEMBL704425
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Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and pharmacological evaluation of potent xanthone dicarboxylic acid leukotriene B4 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.63 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49210 | — | — | 1 | 8.21 |
| CHEMBL288758 | — | — | 1 | 7.37 |
| CHEMBL48068 | — | — | 1 | 6.68 |
| CHEMBL296869 | — | — | 1 | 6.08 |
| CHEMBL297501 | — | — | 1 | 5.75 |
| CHEMBL49209 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49210 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL288758 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL48068 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL296869 | — | IC50 | = | 832.0 | nM | 6.08 |
| CHEMBL297501 | — | IC50 | = | 1766.0 | nM | 5.75 |
| CHEMBL49209 | — | IC50 | = | 2097.0 | nM | 5.68 |