Assay Detail
Functional
CHEMBL704562
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Tested for its antiproliferative activity on murine leukemia L1210 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiproliferative activity of 2-O-allyl-1--D-arabinofuranosyl-uracil, -cytosine and -adenine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.18 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.51 |
| CHEMBL1090 | VIDARABINE | 4.0 | 1 | 4.85 |
| CHEMBL100259 | URIDINE | 3.0 | 1 | - |
| CHEMBL3142860 | — | — | 1 | - |
| CHEMBL3142859 | — | — | 1 | - |
| CHEMBL3142861 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL803 | CYTARABINE | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1090 | VIDARABINE | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL100259 | URIDINE | IC50 | > | 200000.0 | nM | - |
| CHEMBL3142860 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3142859 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL3142861 | — | IC50 | = | 127000.0 | nM | - |