Assay Detail
Binding
CHEMBL705027
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Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
QSAR Study of ortho-phenylphenol leukotriene B4 receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.68 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL167520 | — | — | 1 | 8.52 |
| CHEMBL435273 | — | — | 1 | 8.46 |
| CHEMBL353378 | — | — | 1 | 8.33 |
| CHEMBL167923 | — | — | 1 | 7.79 |
| CHEMBL167850 | — | — | 1 | 7.69 |
| CHEMBL168011 | — | — | 1 | 7.47 |
| CHEMBL167972 | — | — | 1 | 7.42 |
| CHEMBL167261 | — | — | 1 | 7.23 |
| CHEMBL424361 | — | — | 1 | 7.21 |
| CHEMBL166862 | — | — | 1 | 7.20 |
| CHEMBL167580 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL167520 | — | Ki | = | 3.02 | nM | 8.52 |
| CHEMBL435273 | — | Ki | = | 3.467 | nM | 8.46 |
| CHEMBL353378 | — | Ki | = | 4.677 | nM | 8.33 |
| CHEMBL167923 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL167850 | — | Ki | = | 20.42 | nM | 7.69 |
| CHEMBL168011 | — | Ki | = | 33.88 | nM | 7.47 |
| CHEMBL167972 | — | Ki | = | 38.02 | nM | 7.42 |
| CHEMBL167261 | — | Ki | = | 58.88 | nM | 7.23 |
| CHEMBL424361 | — | Ki | = | 61.66 | nM | 7.21 |
| CHEMBL166862 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL167580 | — | Ki | = | 66.07 | nM | 7.18 |