Assay Detail
Functional
CHEMBL705054
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In vitro inhibitory growth activity against L1210 leukemic cells by incubating 5 x 10E4 cells/mL for 48 hour in 2 mL of media.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
2'-Fluorinated isonucleosides. 1. Synthesis and biological activity of some methyl 2'-deoxy-2'-fluoro-2'-pyrimidinyl-D-arabinopyranosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.41 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54918 | 5-FLUOROURIDINE | 2.0 | 1 | 8.52 |
| CHEMBL1794900 | — | — | 1 | 4.47 |
| CHEMBL1794902 | — | — | 1 | 4.40 |
| CHEMBL1794899 | — | — | 1 | 4.26 |
| CHEMBL166343 | — | — | 1 | - |
| CHEMBL1794901 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54918 | 5-FLUOROURIDINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1794900 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1794902 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1794899 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL166343 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1794901 | — | IC50 | > | 1000000.0 | nM | - |